
高文彬 博士 副教授
沧州师范学院
沧州市科技专家库专家
河北省健康科学学会药学专家
wenbinxing@caztc.edu.cn
高文彬,男,汉族,1981年1月出生,中共党员,博士,副教授,校聘教授。目前主持、参与河北省教育厅项目,沧州市科技局项目,国家自然科学基金面上项目、国家重点研发计划项目等项。主要从事从事生物资源开发与利用研究。盐碱地生物资源(植物/微生物)多样性,次生代谢产物的分离纯化、结构鉴定、生物活性筛选及作用机制研究。开发新药、新型兽药、农药及生物菌肥。目前已在《Natural Products and Bioprospecting》、《Journal of Antibiotics》、《Frontiers in Sustainable Food Systems》《Phytochemistry Letters》、《Natural Product Research》、《Chemistry of Natural Compounds》等期刊发表多篇相关论文。
主持或参与项目:
主持,河北省教育厅课题,基于化学指纹分析的连翘次生代谢产物抗肿瘤活性研究(在研)。
主持,河北省教育厅课题,基于省级生物学实验教学示范中心的多层次·多元化实验教学体系的构建与实践(在研)。
主持,沧州市科技局课题,五味子精油成分分析及抗肿瘤转移活性研究(已结题)。
主持,沧州市旱碱麦特色产业研发项目,沧州盐碱地旱碱麦促生增产复合微生物有机碳肥研发与应用(在研)。
主研,国家自然科学基金项目,真菌毒素AcetoxydehydroaustinA的生物合成制及其类似物杀虫活性评价(已结题)。
主研,国家重点研发项目子课题,植物内生真菌代谢物的分离及制备(已结题)。
代表性学术成果:
[1] [1] Saimei Nie1,2† , Wenbin Gao3† , Shasha Liu1 *, Mo Li3 , Tao Li3 , Jing Ren3 , Siyao Ren3 and Jian Wang4 *. Hyperspectral imaging combined with deep learning models for the prediction of geographical origin and fungal contamination in millet [J]. Frontiers in Sustainable Food Systems. 2024. 8: DOI 10.3389/fsufs.2024.1454020.
[2] Jie Wang#, Wen-Bin Gao#, Fan-Wei Liu, Qi Liu, Bo Song, Jin Ye, Ying Chen, Cai-Lin Zhao, Wei dong, Li-na Guo and Bo Song. Two new furanone derivatives from the endophytic fungus Byssochlamys sp. and their cytotoxic activities [J]. Natural Product research. 2023 Oct 27:1-5. doi: 10.1080/14786419.2023.2275269
[3] Wei Dong†, Wen-Bin Gao†, Fan-Wei Liu, Jin-Ye, Ying Chen, Hong-Lian Zhang, Zhen Lv, Li-Na Guo, Bo Song. New α-pyrone and unsaturated ketone analogues from the endophytic fungus Lasiodiplodia sp. and their cytotoxic effects [J]. Phytochemistry Letters. 2023; 56:81-83.
[4] Wenbin Gao, Xiaoxia Wang, Fengli Chen, Chunqing Li, Fei Cao, Duqiang Luo. Setosphlides A-D, New Isocoumarin Derivatives from the Entomogenous Fungus Setosphaeria rostrate LGWB-10 [J]. Natural Products and Bioprospecting, 2021, 11(1): 137-142.
[5] Shasha Liu#, Wenbin Gao#, Xiaohui Yang, Ruiyun Huo, Fengli Chen, Fei Cao, Duqiang Luo. Structure determination and cytotoxic evaluation of metabolites from the entomogenous fungus Fusarium equiseti [J]. Journal of Antibiotics. (Tokyo). 2021;74(3):176-180.
[6] Wen-Bin Gao, Sha-Sha Liu, Ying-Chao Tian, Qian Dong, Jun Zhang, Jian-Chun Qin,and Du-Qiang Luo. Setosphaerine A: A New Chlorinated Polyketide Isolated From the Entomogenous Fungus Setosphaeria rostrata [J]. Natural Product Communications. 2019: 1-3.
[7]Wen-Bin Gao, Li-Ping Han, Fei-Xiang Xie, Qing-Yun Ma, Xiao-Fang Li, Jun Zhang, You-Xing Zhao, and Du-Qiang Luo. A new polyketide-derived metabolite with ptp1b inhibitory activity from the endophytic fungus pestalotiopsis neglecta [J]. Chemistry of Natural Compounds, 2019 ,55(6): 1056-1058.